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Fragment 176-191 – Characteristics, Structure, and Application in Laboratory Research

What is Fragment 176-191?

Fragment 176-191 is a synthetic peptide corresponding to the amino acid sequence from positions 176 to 191 of the human growth hormone (GH). Unlike the full growth hormone molecule, Fragment 176-191 covers only a small section of the amino acid sequence, making it a subject of research in peptide chemistry, molecular biology, and structural biology for many years.

The peptide was developed as a research tool to analyze specific fragments of growth hormone independently of other protein domains. This approach allows researchers to better understand the relationship between the structure of individual amino acid sequences and their biochemical properties.

Chemical Structure

Fragment 176-191 belongs to the group of synthetic peptides obtained by Solid Phase Peptide Synthesis (SPPS). It consists of 16 amino acids corresponding to the terminal fragment of natural human growth hormone.

Due to its precisely defined amino acid sequence, this peptide is used as a research model in analyses concerning peptide structure, physicochemical properties, and methods for identifying peptide compounds.

Its relatively small size means it is also frequently used in the development of analytical methods intended for synthetic peptide research.

Fragment 176-191 as a Subject of Scientific Research

Since this fragment was first described in scientific literature, it has been the subject of numerous studies regarding growth hormone biology and the design of peptide analogs.

Scientific publications dedicated to Fragment 176-191 cover topics including:

• structure analysis of growth hormone fragments,
• relationship between amino acid sequence and peptide properties,
• design of peptide analogs,
• peptide stability,
• peptide chemistry,
• molecular modeling,
• structural biology,
• peptide synthesis methods.

Due to its well-defined structure, Fragment 176-191 is also often used as a reference material in studies on other synthetic peptides.

Application in Laboratory Research

In the scientific community, Fragment 176-191 is primarily used in basic research concerning peptides and proteins.

It most commonly appears in works in the fields of:

• peptide chemistry,
• molecular biology,
• structural biology,
• biochemistry,
• amino acid sequence analysis,
• synthetic peptide design,
• liquid chromatography (HPLC),
• mass spectrometry (LC-MS),
• peptide identification methods.

Scientific publications also describe the use of this peptide in developing analytical methods for the identification and characterization of peptide compounds.

Significance in Peptide Research

Fragment 176-191 is an example of short peptides used to study the relationship between the structure and properties of molecules. Because it corresponds to a precisely defined fragment of growth hormone, it enables research on a single region of this protein without the need to use the full molecule.

This approach is widely used in molecular biology and peptide chemistry, where the analysis of shorter sequences allows for a more thorough investigation of their structural properties and behavior in laboratory conditions.